Dr. Roberto Dominici M.D.
Laureato in Medicina e Chirurgia, Specializzato in Patologia Generale indirizzo immunoematologico (tesi sperimentale degna di menzione: I linfociti T gd (gamma-delta): struttura e funzioni biologiche (50/50 cum laude). Gennaio 96-Feb 1997: Stage post-doc (Visiting scientist) presso l’Istituto di Biologia dell’INSERM, U-463 Nantes (Fr) Interactions ligands et recepteurs in Immunologie et Cancerologie (Dir.: Prof. Marc Bonneville).
Agosto 1999: Ottobre 2000: Borsista associazione Ricerca sulle Demenze (ARD) presso l’Unità di Neuroimmunologia-Dibit Dipartimento di Neuroscienze Ospedale S. Raffaele (HSR) (Laboratorio Luigi Maria Edoardo Grimaldi-Gianvito Martino) di Milano.
Dal 2 Ottobre 2000 fino al 31-12-2009: Dirigente medico Ospedale Luigi Sacco di Milano Laboratorio di Biochimica Clinica, Professore a contratto Università degli Studi di Milano.
Attualmente: Dirigente medico Ospedale G. Fornaroli di Magenta ASST milanese ovest (MI); Laboratorio Analisi Chimico-Cliniche, responsabile settore Elettroforesi e Proteine specifiche. E’ autore di 38 articoli scientifici internazionali e nazionali nell’ambito dell’immunologia, della neurobiologia della malattia di Alzheimer e di Biochimica clinica.
Nel 2008 ha pubblicato il libro: A multidisciplinary approach to dissect the Alzheimer's pathology, edito da Transworld research network.
Nel 2015 ha scritto il Manuale: Guida e supporto pratico per chi assiste un malato di Alzheimer.
The research interests regarded the area of identification and functional characterization of genetic polymorphisms of several genes and molecules such as IL-1 alpha and beta, NOS 3 and hyperomocystein, SEL1L, GPR3, beta2 microglobulin in order to assess their association with the relative risk to develop sporadic form of Alzheimer’ disease
Interests and collaborations:
1. Genome scan of a family with a suspected italian woman affected by Guam syndrome with dr. Daniela Galimberti and Professor Elio Scarpini. We sequenced two genes more frequently observed associated to familiar forms of Fronto-temporal dementia (FTD): progranulin discovered in 2006 as causing of FTLD, and MAPT, discovered in 1998 and that is the 2 cause of FTLD. We have not found mutations in the mentioned genes in the patient affected (data not published).
2. Genotyping and analysis of polimorphisms of GPR3 gene in a coort of italian demented patients (2011)
3. Genotyping and analysis of beta2 microglobulin gene and protein in Mild cognitive impairment, Alzheimer’s patients versus sex and matched normal controls, together with Professor Dario Finazzi fromUniversity of Brescia and Fondazione Golgi-Cenci Abbiategrasso.
2. Genotyping and analysis of polimorphisms of GPR3 gene in a coort of italian demented patients (2011)
3. Genotyping and analysis of beta2 microglobulin gene and protein in Mild cognitive impairment, Alzheimer’s patients versus sex and matched normal controls, together with Professor Dario Finazzi from
4. Collaboration with Department MITB University of Brescia prof. Dario Finazzi and with Department of Neurological Sciences University of Milano- Bicocca
5. Professor Salvatore Oddo Associate Professor, Department of Basic Medical
Sciences Senior Scientist, Banner Sun Health Research Institute (BSHRI), Phoenix, Arizona USA.
6. Dr. Ida Biunno IGB-CNR Role of SEL1L in Quality control of proteins in ERAD system in sporadic Alzheimer’s disease.
7. Collaboration with Dr. Diego Dolcetta Ph.D M.D. neurologist. New protocol of intratecal administration of Rapamicin in several mice models of neurodiseases.
